A new antitumor complex, WF-1360, WF-1360A, B, C, D, E and F.

13.7 Commentary NEW WF

bias, women would still be under-represented in science because they are innately different from men. Lawrence draws from the work of Simon Baron-Cohen in arguing that males are ‘on average’ biologically predisposed to systematize, When I was 14 years old, I had an unusually talented maths teacher. One day after school, I excitedly pointed him out to my mother. To my amazement, she looked at hi...

Studies on WF-3161, a new antitumor antibiotic.

WF-3161 is an antitumor antibiotic produced by a strain of fungus, Petriella guttulata. The antibiotic was purified by solvent extraction and a combination of silica gel and reverse phase column chromatography. The chemical structure of the antibiotic (C31H44N4O6, mp 181-183 degrees C) was found to be a cyclic tetrapeptide consisting of phenylalanine, leucine, pipecolinic acid and 2-amino-8-oxo...

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41-47 News and Views WF IF.indd

5. Hacker, H. & Karin, M. Sci. STKE 2006, re13 (2006). 6. Baud, V. & Karin, M. Nature Rev. Drug Discov. 8, 33–40 (2009). 7. Mayo, M. W. et al. Science 278, 1812–1815 (1997). 8. Chien, Y. et al. Cell 127, 157–170 (2006). 9. Engelman, J. A. et al. Nature Med. 14, 1351–1356 (2008). 10. Dajee, M. et al. Nature 421, 639–643 (2003). Julian Downward is at Cancer Research UK London Research Institute, ...

BE-32030 A, B, C, D and E, new antitumor substances produced by Nocardia sp. A32030.

New antitumor substances, designated BE-32030A, B, C, D and E, were isolated from the culture broth of Nocardia sp. A32030. The active principles were extracted from the mycelium by methanol and purified by Sephadex LH-20 and reversed-phase column chromatographies and finally by reversed-phase HPLC. BE-32030A, B, C, D and E inhibited the growth of P388 murine leukemia, DLD-1 human colon cancer,...